Work

Protein post-translational modifications: In silico prediction tools and molecular modeling

Year: 2017

Type: review

Abstract: Post-translational modifications (PTMs) occur in almost all proteins and play an important role in numerous biological processes by significantly affecting proteins' structure and dynamics. Several computational approaches have been developed to study PTMs ( e.g. , phosphorylation, sumoylation or palmitoylation) showing the importance of these techniques in predicting modified sites that can be further investigated with experimental approaches. In this review, we summarize some of the available online platforms and their contribution in the study of PTMs. Moreover, we discuss the emerging capabilities of molecular modeling and simulation that are able to complement these bioinformatics methods, providing deeper molecular insights into the biological function of post-translational modified proteins.

Source: Computational and Structural Biotechnology Journal

DOI: 10.1016/j.csbj.2017.03.004

Authors: Martina Audagnotto, Matteo Dal Peraro

Institutions: SIB Swiss Institute of Bioinformatics, École Polytechnique Fédérale de Lausanne

Language: English

Topic: Protein Structure and Dynamics

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $3,230

Funders: National Science Foundation, Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung