Year: 2015
Type: article
Abstract: Gene expression is a complex process regulated at many steps.One important step is the degradation of mRNA.The major pathways and enzymes in mRNA decay have been identified and described, but this has not yet led to a good understanding of the mechanisms for the observed differences in mRNA half-lives.Previous research has elucidated several examples of regulation through 3' UTR elements, but general mechanisms are not clear.The translation of mRNA is intricately linked to decay, thus the two processes must be evaluated together to uncover regulation that frequently affects both.We show that the choice of codons in the body of an mRNA can dictate the stability of the mRNA.Messages with a high percentage of optimal codons are relatively stable, whereas messages with a high percentage of non-optimal codons are relatively unstable.Reducing the optimal codon content of a stable message with naturally high occurrence of optimal codon leads to a reduction in stability, and
Author: Vladimir Presnyak
Institution: Case Western Reserve University
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2601150185