Work

Spirochetal Lipoproteins and Immune Evasion

Year: 2017

Type: review

Abstract: Spirochetes are a major threat to public health. However, the exact pathogenesis of spirochetal diseases remains unclear. Spirochetes express lipoproteins that often determine the cross talk between the host and spirochetes. Lipoproteins are pro-inflammatory, modulatory of immune responses, and enable the spirochetes to evade the immune system. In this article, we review the modulatory effects of spirochetal lipoproteins related to immune evasion. Understanding lipoprotein-induced immunomodulation will aid in elucidating innate pathogenesis processes and subsequent adaptive mechanisms potentially relevant to spirochetal disease vaccine development and treatment.

Source: Frontiers in Immunology

DOI: 10.3389/fimmu.2017.00364

Authors: Alexei Christodoulides, Ani Boyadjian, Theodoros Kelesidis

Institution: University of California, Los Angeles

Language: English

Topic: Leptospirosis research and findings

Subfield: Parasitology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801