MRI Based Quantification Of Cerebrovascular Health In Pediatric Subjects With Sickle Cell Disease
Year: 2015
Type: dissertation
Study design: Observational Study
Abstract: Sickle cell disease is a lifelong genetic disorder of the erythrocytes characterized by the sickling of deoxygenated hemoglobin. As a result of the sickling, children with SCD suffer from many different complications such as poor cerebrovascular health, vasculopathies and stroke. Using MR, we can quantify the degree of cerebrovascular health impairment with cerebrovascular reactivity. It was seen that children with SCD had significantly reduced CVR both regionally and globally which was then seen to be correlated with regional measures of cortical thickness. From this study, it was observed that regional deficits in cerebrovascular health are related to regional cortical thinning. Furthermore, previous studies have demonstrated impaired vasculature in patients with obstructive sleep apnea (OSA) which occurs at a high rate in SCD. Therefore, CVR was measured in SCD patients with OSA and compared against SCD patients with no-OSA to determine the effect of OSA in children with SCD.
Source: TSpace (University of Toronto)
Author: Junseok Kim
Language: English
Subfield: Genetics (clinical)
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2602443452