Work

Regulation of mRNA stability by CCCH-type zinc-finger proteins in immune cells

Year: 2017

Type: review

Abstract: Current studies using knockout mice have revealed that some Cys-Cys-Cys-His (CCCH)-type zinc-finger proteins, namely tristetraprolin (TTP), Roquin and Regnase-1, play important roles in the immune system. These proteins are closely associated with the fate of their target RNAs in normal immune responses. However, the functions of many RNA-binding proteins have not been characterized precisely. To understand the molecular mechanisms of RNA metabolism in the immune system, investigation of TTP/Roquin/Regnase-1 might provide new knowledge. In this review, we will discuss the current understanding of these proteins in immune regulation and homeostasis and discuss RNA metabolism in the immune system.

Source: International Immunology

DOI: 10.1093/intimm/dxx015

Authors: Kazuhiko Maeda, Shizuo Akira

Institutions: Immunology Frontier Research Center, The University of Osaka, Research Institute for Microbial Diseases, The University of Osaka, The University of Osaka

Language: English

Topic: RNA Research and Splicing

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,530