Impact of Gaseous Nitric Oxide and Carbon Monoxide on Normal Excisional, Diabetic Excisional and Burn Wound Healing
Year: 2009
Type: article
Abstract: Nitric oxide (NO) and carbon monoxide (CO) are two transmitters that play significant roles in many physiological processes.In pathological conditions such as diabetes or burn the nitrooxidative stress evoked by peroxynitrite formed in reaction between nitric oxide and superoxide contributes to endothelial dysfunction and further leads to an impairment in wound repair.We tested the effect of topical application of nitric oxide and carbon monoxide on excisional wound healing and also diabetic excisional wound and burn wound healing.We investigated the hypothesis of exogenous NO and CO ability to affect [NO]/[ONOO¯] imbalance during progression of wound First, I would like to thank to my advisor, Dr. Tadeusz Malinski, for giving me the opportunity to be a part of his research group and for his scientific expertise, guidance and patience.During my graduate studies I learned a lot from him.He is always inspirational to me, he is full of innovative ideas and his incredible ability of problem solving guided me throughout the ups and downs of my research work.I could not have completed this project without his encouragement and his support.I am extremely thankful for all of that.
Author: Krystian Jasinski
Institution: Ohio University
Language: English
Topic: Wound Healing and Treatments
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2602609995