Aging increases cell-to-cell transcriptional variability upon immune stimulation
Year: 2017
Type: article
Abstract: T cells from young and old mice from two divergent species. In young animals, immunological activation drives a conserved transcriptomic switch, resulting in tightly controlled gene expression characterized by a strong up-regulation of a core activation program, coupled with a decrease in cell-to-cell variability. Aging perturbed the activation of this core program and increased expression heterogeneity across populations of cells in both species. These discoveries suggest that increased cell-to-cell transcriptional variability will be a hallmark feature of aging across most, if not all, mammalian tissues.
Source: Science
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
Awards: Regulatory potential of repeat elements in the evolution of tissue-specific transcription, G1151385638, G1525448996, Hedgehog signalling in T cell effector and memory function in vivo., Hedgehog signalling in T cell effector and memory function in vivo., G2559531292, G3063823482, G3741061449, G4612446324, G4999226567, G518565877, G5200348298, G5478635918, G640145969, G6869293172, G7144121707, G725837782, G7498544051, G7696472789, G7865524347, G7969385195, G8086268091, G8455414079, G8483203165, G8520723716, Wellcome Trust Sanger Institute - generic account for deposition of all core- funded research papers
OpenAlex ID: W2602673171