7. The Neural Mechanisms of Cognitive Control in Psychosis
Year: 2017
Type: conference-abstract
Abstract: Overall Abstract: Over the past 20 years, the field has become increasingly aware of and interested in cognitive dysfunction in psychosis. This is in part because cognitive impairments limit adaptive functioning in psychosis, and thus are a critical treatment focus. Further, such impairments are often present prior to the onset of psychosis and among individuals at risk of psychosis, suggesting that they may provide clues as to pathophysiological mechanisms. This talk will overview the current state of knowledge in regard to cognitive dysfunction in psychosis, with a discussion of the evidence for both specific deficit,s in particular functions validated in basic cognitive neuroscience research and included in the RDoC Cognitive Systems domain (e.g., cognitive control and relational encoding) as well as more general deficits that may cut across cognitive domains. Further, this talk will discuss how we might understand the nature of these more general deficits as a manifestation of the ubiquitous importance of cognitive control, and the ability to rapidly establish, use, and maintain representations of intended task states and goals. Important, the evidence suggests that many of these deficits are present across the spectrum of psychotic disorders and are even detectable among individuals in the general population who may exhibit subclinical manifestation of psychosis. This talk will also overview evidence in regard to the neurobiological mechanisms that may contribute to these cognitive deficits, with a particular focus on the role of the frontal–parietal network and the cingulo-opercular networks, both in terms of activation and in terms of connectivity, as well as the relative contributions of abnormalities in a number of neurotransmitter systems, including dopamine, glutamate, and GABA. Finally, this talk will raise the question of whether cognitive control deficits might be core to the “P” factor of psychopathology. Concurrent Oral Presentations
Source: Schizophrenia Bulletin
Author: Deanna Barch
Institution: Washington University in St. Louis
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2603168442