Pd28-11 Prospective Study of Biopsy Decipher Scores in Potential Candidates for Active Surveillance
Year: 2017
Type: article
Study design: Observational Study
Abstract: biopsy.The median interval between MRI and repeat biopsy was 2.6 months.Sixty-seven percent of men (57 of 86) showed at least one PIRADS 4 or 5 lesion.Twenty-seven (31%) of men had disease reclassification on confirmatory biopsy including seven men with Gleason 8 or 9 disease.18.5% of men with no identifiable or PIRADS 1-3 lesions had grade reclassification compared with 42% of men with PIRADS 4 or 5 lesions.(p¼0.03).All grade reclassification in patients with lesions characterized as PIRADS 3 or less was from 3+3 to 3+4.Of the 42% of men with PIRADS 4 or 5 lesions who reclassified on confirmatory biopsy, 7/57 (12%) reclassified to Gleason 8 or 9 on confirmatory biopsy.CONCLUSIONS: Men on active surveillance with no identified or PIRADS ¼3 lesions on mp-MRI are still at risk for disease reclassification on repeat biopsy, although no high-risk cancers are missed by MRI.Men with PIRADS 4 or 5 lesions are at higher risk for reclassification including to Gleason 8-10 disease after repeat biopsy.
Source: The Journal of Urology
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2604362668