Work

Helicobacter pylorirecurrence after eradication in Latin America: Implications for gastric cancer prevention

Year: 2017

Type: article

Study designs: Systematic Review, Meta-Analysis

Abstract: AIM: prevalence and gastric cancer burden. METHODS: statistic assessed between study heterogeneity. Meta-regression analyses evaluated for effect modifying variables. RESULTS: Literature search yielded 163 articles. Twelve studies involving 4848 patients from 9 countries met inclusion criteria. Four hundred and thirty-two reinfections were recorded in 5487 person-years of follow-up. Pooled analysis showed a recurrence rate of 7.9 cases per 100 person-years (95%CI: 5.3-10.5). Meta-regression revealed that neither the antibiotic schema, a second antibiotic course, nor the diagnostic modality had an impact on the observed risk of recurrence. The recurrence rate in the first year after treatment, predominantly recrudescence, was 11.2 (6.1-16.4) per 100 patient years. Recurrence in subsequent years, was only 6.2 (3.8-8.7). CONCLUSION: recurrence rates in Latin America are significant, and with geographic variability, yet are acceptable based upon the current literature for consideration of large scale intervention trials. Further research in Latin America is warranted to evaluate the efficacy, cost-effectiveness, and potential adverse outcomes of proposed eradication programs.

Source: World Journal of Gastrointestinal Oncology

DOI: 10.4251/wjgo.v9.i4.184

Authors: Juan E Corral, Robertino Mera, Corey W Dye, Douglas R Morgan

Institutions: Vanderbilt University, Mayo Clinic in Florida, University of Miami

Language: English

Topic: Helicobacter pylori-related gastroenterology studies

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: National Institutes of Health, National Cancer Institute