Evolution of the hypoxia-sensitive cells involved in amniote respiratory reflexes
Year: 2017
Type: article
Abstract: The evolutionary origins of the hypoxia-sensitive cells that trigger amniote respiratory reflexes - carotid body glomus cells, and 'pulmonary neuroendocrine cells' (PNECs) - are obscure. Homology has been proposed between glomus cells, which are neural crest-derived, and the hypoxia-sensitive 'neuroepithelial cells' (NECs) of fish gills, whose embryonic origin is unknown. NECs have also been likened to PNECs, which differentiate in situ within lung airway epithelia. Using genetic lineage-tracing and neural crest-deficient mutants in zebrafish, and physical fate-mapping in frog and lamprey, we find that NECs are not neural crest-derived, but endoderm-derived, like PNECs, whose endodermal origin we confirm. We discover neural crest-derived catecholaminergic cells associated with zebrafish pharyngeal arch blood vessels, and propose a new model for amniote hypoxia-sensitive cell evolution: endoderm-derived NECs were retained as PNECs, while the carotid body evolved via the aggregation of neural crest-derived catecholaminergic (chromaffin) cells already associated with blood vessels in anamniote pharyngeal arches.
Source: eLife
DOI: 10.7554/elife.21231
Institutions: University of Cape Town, University of Cambridge, University of Oxford, MRC Weatherall Institute of Molecular Medicine, Washington University in St. Louis, Erasmus MC, Takeda (United States), University College London, Ollscoil na Gaillimhe – University of Galway, Sanford Burnham Prebys Medical Discovery Institute, University of California, Santa Barbara, Max Planck Institute for Developmental Biology, Boston University, University of Pennsylvania, Vanderbilt University, Vanderbilt University Medical Center, Boston Children's Hospital, Howard Hughes Medical Institute, Harvard University, California NanoSystems Institute, University of Zurich, Helmholtz Munich, King's College London
Language: English
Subfield: Endocrine and Autonomic Systems
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,500
Funders: National Science Foundation, Vanderbilt University, California Institute of Technology, University of Portsmouth, Wellcome Trust, Cambridge Philosophical Society, University of Oxford, Human Frontier Science Program, Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung, Università degli Studi di Messina, Ernest Oppenheimer Memorial Trust, National Institutes of Health, Biotechnology and Biological Sciences Research Council, National Heart, Lung, and Blood Institute, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Dental and Craniofacial Research, Deutsches Zentrum für Diabetesforschung
Awards: Consequences of the dual origin of the middle ear epithelium on function., Unlocking Regenerative Potential through in Vivo Genetic Reprogramming, G2533487694, Cranial suture formation in the zebrafish, G4391387013, The development of neutral crest-derived chemosensory cells., THE ROLE OF THE SECRETORY PATHWAY IN CRANIOFACIAL MORPHOGENESIS, G8270686962, G9000171545, G9000201173
OpenAlex ID: W2604404863