Work

Mp39-01 Characterizing Recurrent and Lethal Small Renal Masses in Clear Cell Renal Cell Carcinoma Using Somatic Mutations

Year: 2017

Type: article

Abstract: 25.5% had Gleason 6, 25.5% had Gleason 7, and 9.0%, had Gleason 8-10 on final histopathology.Fusion Biopsy of PIRADSv2 3 lesions (n¼66) revealed no cancer in 65.2%, Gleason 6 in 15.2%, Gleason 7 in 19.7% and Gleason 8-10,in 0% of patients.Of 83 patients with clinically significant cancer, 26 (31.3%) would have been missed on standard biopsy and 12 (14.5%)would have been missed using fusion biopsy alone.Concordance between both biopsy modalities was 63.1%.CONCLUSIONS: mp-MRI targeted fusion biopsy improves the detection of clinically significant prostate cancer in select patients.However, our results demonstrate that a significant proportion of these cancers will not be detected by a targeted biopsy alone.Therefore, standard template biopsies should remain an integral component of any fusion biopsy program.

Source: The Journal of Urology

DOI: 10.1016/j.juro.2017.02.1175