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Mp34-14 the Effect of Adjuvant Chemotherapy for Patients With Adverse Pathology After Neoadjuvant Chemotherapy for Muscle-invasive Bladder Cancer

Year: 2017
Type: article
Abstract: increased RhoGDIb mRNA stability which then promotes invasion.Indeed, inhibition of ATG7-mediated autophagy led to AUF1 protein accumulation, RhoGDIb downregulation and decreased cell invasion.CONCLUSIONS: Our results provide the first mechanistic link between autophagy and bladder cancer cell invasion.The signaling axis along ATG7-AUF1-RhoGDI' that is highly operative in bladder cancer cells might be explored further for developing novel diagnostic and therapeutic approaches to manage advanced bladder cancers.
DOI: 10.1016/j.juro.2017.02.1031
Authors: William Parker, Elizabeth Habermann, Courtney Day, Harras Zaid, Igor Frank, R. Houston Thompson, Matthew Tollefson, Stephen Boorjian, Lance Pagliaro, R. Jeffrey Karnes
Language: English
Subfield: Surgery
Field: Medicine
Open Access status: bronze
Awards: G1746122051, G1963369394, G2033361267, G2999242660, G3021935383, G4247598040, G450454975, G7694451503, G8045722022, Molecular Mechanisms of Nickel-induced Tumorigenicity., Mechanisms underlying therapeutic effect of a new compound Isorhapontigenin (ISO), G9000184592, G9000300057
OpenAlex ID: W2604544261
FWCI:
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