Work

Chemical signaling between gut microbiota and host chromatin: What is your gut really saying?

Year: 2017

Type: review

Abstract: Mammals and their gut microbial communities share extensive and tightly coordinated co-metabolism of dietary substrates. A large number of microbial metabolites have been detected in host circulation and tissues and, in many cases, are linked to host metabolic, developmental, and immunological states. The presence of these metabolites in host tissues intersects with regulation of the host's epigenetic machinery. Although it is established that the host's epigenetic machinery is sensitive to levels of endogenous metabolites, the roles for microbial metabolites in epigenetic regulation are just beginning to be elucidated. This review focuses on eukaryotic chromatin regulation by endogenous and gut microbial metabolites and how these regulatory events may impact host developmental and metabolic phenotypes.

Source: Journal of Biological Chemistry

DOI: 10.1074/jbc.r116.761577

Authors: Kimberly A. Krautkramer, Federico E. Rey, John M. Denu

Institutions: University of Wisconsin–Madison, Wisconsin Institutes for Discovery, Morgridge Institute for Research

Language: English

Topic: Gut microbiota and health

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $3,430

Funders: National Institutes of Health, National Institute of Food and Agriculture, National Institute of General Medical Sciences, National Institute of Diabetes and Digestive and Kidney Diseases