Work

Inflammasome activation by nucleic acids and nucleosomes in sterile inflammation… or is it sterile?

Year: 2017

Type: article

Abstract: Inflammasomes are multiprotein complexes that form in the cytoplasm in response to cellular damage and cytosolic pathogen-associated molecules during infection. These complexes play important roles in initiating innate and adaptive immune responses to infectious disease. In addition, inflammasomes are now recognized as important mediators of sterile inflammation in various autoimmune and autoinflammatory diseases. Interestingly, microbiota and infection play critical roles in the development of 'sterile inflammation'. Herein, we highlight recent advances in our understanding of the role for inflammasomes in nucleic acid-, nucleosome-, and histone-driven sterile inflammation and discuss knowledge gaps and areas of potential future research.

Source: FEBS Journal

DOI: 10.1111/febs.14076

Authors: Christopher R. Lupfer, Angeline Rodriguez, Thirumala‐Devi Kanneganti

Institutions: Missouri State University, St. Jude Children's Research Hospital

Language: English

Topic: Inflammasome and immune disorders

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze