Power And Sample Size Considerations In A Pre-Maturely Terminated Randomized, Double-Mask, Placebo-Controlled, Dose-Response, Phase 2 Study Of The Safety And Efficacy Of Thymosin Beta 4 For The Treatment Of Persistent Corneal Epithelial Defects Resulting
Year: 2011
Type: article
Study design: Clinical Trial
Abstract: Persistent corneal epithelial defects (PED) are a challenging clincial condition to treat.Recently, Thymosin Beta 4 (T!4) has been under investigation as a novel compound for the treatment of PED.We performed a prospective, randomized clinical trial to evaluate the safety and efficacy of T!4 in the treatment of PED in diabetics who underwent corneal epithelial debridement during vitrectomy surgery.Although the trial was closed prematurely due to slow enrollment, the data that was collected was analyzed.In addition, study design considerations with specific regard to possible future studies are discussed.
Author: Bennie H. Jeng
Institution: Case Western Reserve University
Language: English
Subfield: Statistics and Probability
Field: Mathematics
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W2604745677