Work

Act1: A Psoriasis Susceptibility Gene Playing its Part in Keratinocytes

Year: 2017

Type: article

Abstract: Unchecked inflammation, impaired keratinocyte differentiation, and heightened host defense responses typify psoriasis. Lambert et al. make clever use of psoriasis patient genetics and whole transcriptome RNA-Seq analysis to implicate Act1 in these seemingly variegated processes by keeping IL-17 receptor signaling in check while supporting differentiation and limiting innate immune responses in human keratinocytes.

Source: Journal of Investigative Dermatology

DOI: 10.1016/j.jid.2017.01.023

Authors: Ryan P. Hobbs, Susan H. Smith, Spiro Getsios

Institutions: Johns Hopkins University, GlaxoSmithKline (United States)

Language: English

Topic: Psoriasis: Treatment and Pathogenesis

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,800