Direct evidence for a polygenic etiology in familial multiple myeloma
Year: 2017
Type: article
Study design: Observational Study
Abstract: , respectively). Using mixture modeling, we estimate that about one-third of familial cases result from such enrichments. Our results provide the first direct evidence for a polygenic etiology in a familial hematologic malignancy.
Source: Blood Advances
Authors: Britt-Marie Halvarsson, Anna-Karin Wihlborg, Mina Ali, Konstantinos Lemonakis, Ellinor Johnsson, Abhishek Niroula, Carrie Cibulskis, Niels Weinhold, Asta Försti, Evren Alici, Christian Langer, Michael Pfreundschuh, Hartmut Goldschmidt, Ulf-Henrik Mellqvist, Ingemar Turesson, Anders Waage, Kari Hemminki, Todd Golub, Hareth Nahi, Urban Gullberg, Markus Hansson, Björn Nilsson
Institutions: Lund University, Skåne University Hospital, Broad Institute, Heidelberg University, German Cancer Research Center, Karolinska Institutet, Universität Ulm, Saarland University, National Center for Tumor Diseases, Sahlgrenska University Hospital, Norwegian University of Science and Technology
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,800
OpenAlex ID: W2605155192