Work

EFAD transgenic mice as a human APOE relevant preclinical model of Alzheimerŉs disease

Year: 2017

Type: review

Abstract: -modulated symptoms of AD pathology. From their first description in 2012, EFAD mice have enabled critical basic and therapeutic research. Here we review insights gleaned from the EFAD mice and summarize future directions.

Source: Journal of Lipid Research

DOI: 10.1194/jlr.r076315

Authors: Leon M. Tai, Deebika Balu, Evangelina Avila-Munoz, Laila Abdullah, Riya Thomas, Nicole Collins, Ana Carolina Valencia-Olvera, Mary Jo LaDu

Institutions: University of Illinois Chicago, Roskamp Institute

Language: English

Topic: Alzheimer's disease research and treatments

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,430

Funders: National Institutes of Health, National Institute on Aging, National Institute of Neurological Disorders and Stroke

Awards: Preclinical assessment of an ABCA1 agonist as a novel therapeutic for AD, Potential ApoE Isoform-Specific Detrimental Effects of RXR Agonists in Alzheimer', Aged EFAD mice as a model for the effects of APOE and sex on AD pathology

OpenAlex ID: W2605159920

FWCI: 0.881

Cites: 358

Cited by: 98

Related to: 10