Work

The role of integration in oncogenic progression of HPV-associated cancers

Year: 2017

Type: article

Abstract: How does integration of HPV promote oncogenesis?Almost all HPV integration events that have been studied in detail to date are related to HPV oncogenesis.HPV integration events can be detected in premalignant lesions, but the percentage of cells containing integrated HPV increases as cells progress to invasive cancer [5].Integration usually results in dysregulation of expression of the viral E6 and E7 oncogenes, which promotes cellular proliferation, abrogates cell cycle checkpoints, and causes progressive genetic instability.This gives cells a selective growth advantage and promotes oncogenic progression [6].Clonal outgrowth of cells with integrated HPV highlights the importance of

Source: PLoS Pathogens

DOI: 10.1371/journal.ppat.1006211

Authors: Alison A. McBride, Alix Warburton

Institutions: National Institutes of Health, National Institute of Allergy and Infectious Diseases

Language: English

Topic: Cervical Cancer and HPV Research

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,043