V4-02 Gold Nano-particle Directed Focal Laser Ablation for Prostate Tumors Using Us and Mr Fusion Technology
Year: 2017
Type: article
Abstract: You have accessJournal of UrologyImaging/Uroradiology1 Apr 2017V4-02 GOLD NANO-PARTICLE DIRECTED FOCAL LASER ABLATION FOR PROSTATE TUMORS USING US AND MR FUSION TECHNOLOGY Jared S Winoker, Pratik A Shukla, Michael A Carrick, Harry Anastos, Cynthia J Knauer, Ashutosh K Tewari, Bachir M Taouli, Sara C Lewis, Jon A Schwartz, Joshua M Stern, Steven E. Canfield, and Ardeshir Rastinehad Jared S WinokerJared S Winoker More articles by this author , Pratik A ShuklaPratik A Shukla More articles by this author , Michael A CarrickMichael A Carrick More articles by this author , Harry AnastosHarry Anastos More articles by this author , Cynthia J KnauerCynthia J Knauer More articles by this author , Ashutosh K TewariAshutosh K Tewari More articles by this author , Bachir M TaouliBachir M Taouli More articles by this author , Sara C LewisSara C Lewis More articles by this author , Jon A SchwartzJon A Schwartz More articles by this author , Joshua M SternJoshua M Stern More articles by this author , Steven E. CanfieldSteven E. Canfield More articles by this author , and Ardeshir RastinehadArdeshir Rastinehad More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2017.02.901AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES : A growing collective proficiency in multiparametric magnetic resonance imaging (mpMRI) and targeted biopsies for prostate cancer (PCa) screening has given way to an increasing interest in the application of these technologies for targeted therapy. Various targeted therapies have been developed and evaluated; however, these treatments focus energy at a region of the prostate, as opposed to directly at the tumor. Gold nanoparticle (GNP) therapy is a novel treatment that results in tumor-specific ablation, sparing surrounding tissue and structures. Herein, we report the first two cases in the world using gold nanoparticle-directed focal laser ablation of prostate tumors targeted with ultrasound (US) and MR/US fusion technology. METHODS Patients were enrolled in a phase II trial, ′A Study of MRI/US Fusion Imaging and Biopsy in Combination with Nanoparticle Directed Focal Therapy for Ablation of Prostate Tissue.′ Treatment and follow up plan are as follows: intravenous infusion on day 0, which allows GNP deposition into the tumors with the goal of achieving a 15.2 µg/cc tumor concentration required for excitation/ablation. On day 1, the patient presents for focal laser excitation of the GNPs. Laser catheters are placed using a combination of US and a transperineal electromagnetic-tracked MR/US fusion device (Invivo, Gainesville, FL). 48 hours' post-ablation, the patient is imaged, fig 1, followed by re-imaging and MR/US fusion guided biopsy (FBx) at 3 months. All patient demographics, clinical variables, and complications were recorded. RESULTS To date, 2 patients have been enrolled in the trial, both with localized Gleason 7 PCa diagnosed using MR/US FBx. Mean age was 67 + 4.3 years and mean prostate specific antigen was 6.1 + 0.06 ng/ml. The mean tumor volume was 0.40 + 0.05 cc with a solitary lesion in each patient. The mean PSA decrease was 3.6 + 0.6 ng/ml, a 40.9% decrease at 1 month. No short-term complications were observed. The first patient underwent a follow up FBx at 3 months with no detectable cancer. CONCLUSIONS Increasing interest in image guidance technologies and focal therapies has sparked a new generation of PCa treatment modalities. We have demonstrated the first safe and effective use of ultra-focal therapy using MR/US fusion technology in concert with GNP directed therapy to treat prostate tumors. © 2017FiguresReferencesRelatedDetails Volume 197Issue 4SApril 2017Page: e375-e376 Advertisement Copyright & Permissions© 2017MetricsAuthor Information Jared S Winoker More articles by this author Pratik A Shukla More articles by this author Michael A Carrick More articles by this author Harry Anastos More articles by this author Cynthia J Knauer More articles by this author Ashutosh K Tewari More articles by this author Bachir M Taouli More articles by this author Sara C Lewis More articles by this author Jon A Schwartz More articles by this author Joshua M Stern More articles by this author Steven E. Canfield More articles by this author Ardeshir Rastinehad More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...
Source: The Journal of Urology
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2605279083