Work

Systematic review indicates postnatal growth in term infants born small‐for‐gestational‐age being associated with later neurocognitive and metabolic outcomes

Year: 2017

Type: review

Study design: Systematic Review

Abstract: We systematically reviewed papers published in English between 1994 and October 2015 on how postnatal weight gain and growth affect neurodevelopment and metabolic outcomes in term-born small-for-gestational-age (SGA) infants. Two randomised trials reported that enriched infant formulas that promoted early growth also increased fat mass, lean mass and blood pressure (BP), but had no effect on early neurocognitive outcomes. Meanwhile, 31 observational studies reported consistent positive associations between postnatal weight gain and growth with neurocognitive outcomes, adiposity, insulin resistance and BP. CONCLUSION: Few intervention studies exist, despite consistent positive associations between early growth and neurocognition in term-born SGA infants.

Source: Acta Paediatrica

DOI: 10.1111/apa.13868

Authors: Esther Castanys‐Muñoz, Kathy Kennedy, Eurídice Castañeda‐Gutiérrez, Stewart Forsyth, Keith M. Godfrey, Berthold Koletzko, Susan E. Ozanne, Ricardo Rueda, Marieke Schoemaker, Eline M. van der Beek, Stef van Buuren, Ken K. Ong

Institutions: Great Ormond Street Hospital, University College London, Nestlé (Switzerland), University Hospital Southampton NHS Foundation Trust, NIHR Southampton Biomedical Research Centre, MRC Lifecourse Epidemiology Unit, University of Southampton, Ludwig-Maximilians-Universität München, University of Cambridge, Wellcome/MRC Institute of Metabolic Science, MRC Metabolic Diseases Unit, Abbott (Spain), Mead Johnson (United States), University Medical Center Groningen, Nutricia Research (Netherlands), Danone Nutricia Research (Netherlands), Netherlands Organisation for Applied Scientific Research, Utrecht University, MRC Epidemiology Unit

Language: English

Topic: Birth, Development, and Health

Subfield: Pediatrics, Perinatology and Child Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,480

Funders: National Institute for Health and Care Research, British Heart Foundation, Medical Research Council

Awards: NIHR Senior Investigator Award, Epigenetic biomarkers and determinants of cardiovascular risk in children, Assessment of LifeLab Southampton: engaging teenagers in increasing their interest in science to improve their health behaviours, Nutrition, Development and Lifelong Health: Studies in European Populations, Child Growth and development

OpenAlex ID: W2605287062

FWCI: 3.005

Cites: 55

Cited by: 117

Related to: 10