Fruit and vegetable intake and prostate cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC)
Year: 2017
Type: article
Study design: Observational Study
Abstract: Several dietary factors have been studied in relation to prostate cancer; however, most studies have not reported on subtypes of fruit and vegetables or tumor characteristics, and results obtained so far are inconclusive. This study aimed to examine the prospective association of total and subtypes of fruit and vegetable intake with the incidence of prostate cancer overall, by grade and stage of disease, and prostate cancer death. Lifestyle information for 142,239 men participating in the European Prospective Investigation into Cancer and Nutrition from 8 European countries was collected at baseline. Multivariable Cox regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). After an average follow‐up time of 13.9 years, 7,036 prostate cancer cases were identified. Compared with the lowest fifth, those in the highest fifth of total fruit intake had a significantly reduced prostate cancer risk (HR = 0.91; 95% CI = 0.83–0.99; p‐trend = 0.01). No associations between fruit subtypes and prostate cancer risk were observed, except for citrus fruits, where a significant trend was found (HR = 0.94; 95% CI = 0.86–1.02; p‐trend = 0.01). No associations between total and subtypes of vegetables and prostate cancer risk were observed. We found no evidence of heterogeneity in these associations by tumor grade and stage, with the exception of significant heterogeneity by tumor grade (pheterogeneity<0.001) for leafy vegetables. No significant associations with prostate cancer death were observed. The main finding of this prospective study was that a higher fruit intake was associated with a small reduction in prostate cancer risk. Whether this association is causal remains unclear.
Source: International Journal of Cancer
DOI: 10.1002/ijc.30741
Authors: Aurora Perez‐Cornago, Ruth C. Travis, Paul N. Appleby, Konstantinos K. Tsilidis, Anne Tjønneland, Anja Olsen, Kim Overvad, Verena Katzke, Tilman Kühn, Antonia Trichopoulou, Eleni Peppa, Maria Kritikou, Sabina Sieri, Domenico Palli, Carlotta Sacerdote, Rosario Tumino, H. B(as) Bueno‐de‐Mesquita, Antonio Agudo, Nerea Larrañaga, Elena Molina‐Portillo, Eva Ardanaz, Maria‐Dolores Chirlaque, Cristina Lasheras, Pär Stattin, Maria Wennberg, Isabel Drake, Johan Malm, Julie A. Schmidt, Kay‐Tee Khaw, Marc Gunter, Heinz Freisling, Inge Huybrechts, Dagfinn Aune, Amanda J Cross, Elio Riboli, Timothy J. Key
Institutions: University of Oxford, University of Ioannina, Imperial College London, Danish Cancer Society, Aarhus University, German Cancer Research Center, National and Kapodistrian University of Athens, Hellenic Health Foundation, Fondazione IRCCS Istituto Nazionale dei Tumori, Istituto per lo Studio e la Prevenzione Oncologica, Piedmont Reference Center for Epidemiology and Cancer Prevention, University of Turin, Azienda Usl 8 Arezzo, University of Malaya, National Institute for Public Health and the Environment, Institut d'Investigació Biomédica de Bellvitge, Institut Català d'Oncologia, Basque Government, Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, Universidad de Granada, Instituto de Investigación Biosanitaria de Granada, Andalusian School of Public Health, Instituto de Salud Pública de Navarra, Navarre Institute of Health Research, Instituto Murciano de Investigación Biosanitaria, Universidad de Murcia, Universidad de Oviedo, Uppsala University, Umeå University, Lund University, Skåne University Hospital, University of Cambridge, Centre international de recherche sur le cancer
Language: English
Topic: Nutritional Studies and Diet
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,192
Funders: Ecumenical Project for International Cooperation, World Health Organization, Deutsches Krebsforschungszentrum, Centre International de Recherche sur le Cancer, Cancer Research UK, National Institute for Health and Care Research, European Commission, Bundesministerium für Bildung und Forschung, Cancerfonden, Vetenskapsrådet, Associazione Italiana per la Ricerca sul Cancro, Deutsche Krebshilfe, Hellenic Health Foundation, Medical Research Council, World Cancer Research Fund, Instituto de Salud Carlos III, European Regional Development Fund
Awards: G1032970344, G1055973116, G1075502044, G1192877484, G1208621354, G1274701479, G1559294051, G172151099, G1767199718, G1788645866, G1993546569, G2092716656, G2149865848, G2235605558, G2336049343, G2409987178, G2539064604, G2561548287, G2611591051, G2742323354, G2841678936, G2871896171, G2933204024, G3010599472, G3077395769, G3084320185, G3189789075, G3216658785, G331404038, G3452641779, G3675143906, G375319704, G382879149, G3980646122, G4015216323, G4041385912, G4049848471, G4081633361, G4089957676, G4187108342, G4213141252, G4305317257, G43956866, Health of vegetarians, G4682079261, G4752739612, G4811780622, G4879533352, G4884057766, G4913827001, G5004963360, G5119219000, G5375816427, G5406065712, G5651954792, G569447510, G569908600, G5706284561, G5750710683, G5897142711, G5990830295, G6085534252, NIHR Senior Investigator Award, G6212483348, G6320156643, G6442500046, G657255654, G6594529311, G6639096045, G6723261869, G6779186093, G6820515600, G6960682749, G7040807446, G7086224842, G7306252069, G7447125227, G7597388277, G7600088736, G7624991799, G7646326732, G7853538257, G7983476435, G8050896463, G817390530, G8279237360, G8331243404, G8374761964, G8407261631, G8500560359, G8508326818, G8525262851, G8867963557, G8869854444, G8959392569, G8978728421, G9000009928, G9000332718
OpenAlex ID: W2605397824