Work

Dual targeting of EGFR and glutaminase in lung cancer

Year: 2017

Type: editorial

Abstract: We have recently demonstrated that targeted inhibition of epidermal growth factor receptor (EGFR) signaling and glutaminase led to metabolic crisis in EGFR mutant lung adenocarcinomas and significant tumor regression in mouse xenograft models. Combining targeted therapies that restrict the metabolic activity and growth of tumors represents a therapeutic strategy that holds promise for clinical translation.

Source: Molecular & Cellular Oncology

DOI: 10.1080/23723556.2017.1297883

Authors: Milica Momcilovic, David B. Shackelford

Institution: University of California, Los Angeles

Language: English

Topic: Lung Cancer Treatments and Mutations

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Stop Cancer, National Institutes of Health, David Geffen School of Medicine, University of California, Los Angeles