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Lamin B1 is required for mature neuron-specific gene expression during olfactory sensory neuron differentiation

Year: 2017
Type: article
Abstract: B-type lamins are major constituents of the nuclear lamina in all metazoan cells, yet have specific roles in the development of certain cell types. Although they are speculated to regulate gene expression in developmental contexts, a direct link between B-type lamins and developmental gene expression in an in vivo system is currently lacking. Here, we identify lamin B1 as a key regulator of gene expression required for the formation of functional olfactory sensory neurons. By using targeted knockout in olfactory epithelial stem cells in adult mice, we show that lamin B1 deficient neurons exhibit attenuated response to odour stimulation. This deficit can be explained by decreased expression of genes involved in mature neuron function, along with increased expression of genes atypical of the olfactory lineage. These results support that the broadly expressed lamin B1 regulates expression of a subset of genes involved in the differentiation of a specific cell type.
DOI: 10.1038/ncomms15098
Authors: Crystal M. Gigante, Michele Dibattista, Frederick N. Dong, Xiaobin Zheng, Sibiao Yue, Stephen G. Young, Johannes Reisert, Yixian Zheng, Haiqing Zhao
Institutions: Johns Hopkins University, Carnegie Institution for Science, Department of Embryology, Monell Chemical Senses Center, University of Bari Aldo Moro, University of California, Los Angeles
Language: English
Open Access status: gold
Estimated APC paid: $6,990
Funders: Ellison Medical Foundation, National Institutes of Health, National Institute on Aging, National Heart, Lung, and Blood Institute, National Institute on Deafness and Other Communication Disorders, National Institute of General Medical Sciences
Awards: Analysis of lamin-chromatin interactions and their regulation of chromosome organization and gene expression, Improvement to the Animal Facility HVAC System at the Monell Chemical Senses Center, ZMPSTE24, HIV treatment regimens, and atherosclerotic heart disease, G3824716489, CaaX Protein Processing and Human Disease, The function and assembly of the lamin-B spindle sheath, Regulation of Olfactory Signal Transduction, Cellular and Molecular Biology, Mechanisms of chromosome segregation and mitotic timing
OpenAlex ID: W2605664654
FWCI: 1.451
Cites: 71
Cited by: 32
Related to: 10