The characteristics of newly diagnosed adult early-onset diabetes: a population-based cross-sectional study
Year: 2017
Type: article
Study design: Observational Study
Abstract: To investigate the characteristics of newly diagnosed early-onset diabetes in the Chinese population, 2801 newly diagnosed diabetes participants without known diabetes or pre-diabetes in a national cross-sectional survey were analysed. Participants were divided into quartiles (22–43, 44–52, 53–61 and >61 years) according to age of diabetes onset and the first group were defined as early-onset diabetes group. Early-onset diabetes group had lower systolic blood pressure (SBP), total cholesterol, low density lipoprotein cholesterol, 2-hour post prandial blood glucose and urine albumin creatinine ratio. There was no difference in body mass index, Homeostasis model assessment (HOMA) of beta cell function and diabetes family history between early-onset diabetes participants and any other age groups. HOMA of insulin resistance (IR) scores and disposition index 30 minutes after glucose load (DI30) were increased in early-onset diabetes participants. The beta cell function declination was more deteriorated in early-onset diabetes participants. Male gender, triglycerides, HOMA-IR and DI30 were positively associated with an earlier age at diagnosis. In conclusion, patients diagnosed with diabetes at a younger age are characterized by a similar cardiovascular risk profile with increased insulin resistance and more severe beta cell failure than patients diagnosed at a later age.
Source: Scientific Reports
DOI: 10.1038/srep46534
Institutions: Peking University People's Hospital, China-Japan Friendship Hospital, Chinese People's Liberation Army, Sun Yat-sen University, Third Affiliated Hospital of Sun Yat-sen University, Shanghai Jiao Tong University, Shanghai Sixth People's Hospital, First Hospital of China Medical University, Shanxi Provincial People’s Hospital, Sichuan University, West China Hospital of Sichuan University, Xijing Hospital, Air Force Medical University, Nanjing Drum Tower Hospital, Nanjing University, People's Hospital of Xinjiang Uygur Autonomous Region, Fujian Provincial Hospital, Qilu Hospital of Shandong University, Peking University First Hospital, Henan Provincial People's Hospital, Harbin Medical University, Second Affiliated Hospital of Harbin Medical University, Second Xiangya Hospital of Central South University
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,690
OpenAlex ID: W2605748423