Work

Statins as Inhibitors of Lung Cancer Bone Metastasis

Year: 2017

Type: article

Abstract: Bone metastases from lung cancer are common events affecting 30–40% advanced lung cancer patients, causing extremely debilitating pain, fracture and spinal compression (Popper, 2016). Cancer cells metastasize to the bone and induce an osteolytic lesion by activating osteoclasts. In addition to conventional treatment of surgery and radiotherapy coupled with pain management, two osteoclast inhibitors, bisphosphonates and the anti-RANKL antibody Denosumab, are currently used for treatment of bone metastasis (D'Antonio et al., 2014).

Source: EBioMedicine

DOI: 10.1016/j.ebiom.2017.04.028

Author: Devanand Sarkar

Institutions: Virginia Commonwealth University, VCU Massey Comprehensive Cancer Center

Language: English

Topic: Bone health and treatments

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $5,780