Work

Evaluation of a Live Attenuated Human Metapneumovirus Vaccine in Adults and Children

Year: 2017

Type: article

Abstract: We conducted a phase I clinical trial of an experimental live attenuated recombinant human metapneumovirus (HMPV) vaccine (rHMPV-Pa) sequentially in adults, HMPV-seropositive children, and HMPV-seronegative children, the target population for vaccination. rHMPV-Pa was appropriately restricted in replication in adults and HMPV-seropositive children but was overattenuated for HMPV-seronegative children.

Source: Journal of the Pediatric Infectious Diseases Society

DOI: 10.1093/jpids/pix006

Authors: Ruth A Karron, Jocelyn San Mateo, Kimberli Wanionek, Peter L Collins, Ursula J Buchholz

Institutions: Johns Hopkins University, National Institutes of Health, National Institute of Allergy and Infectious Diseases

Language: English

Topic: Respiratory viral infections research

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,752