Decreased body mass index in the preclinical stage of autosomal dominant Alzheimer’s disease
Year: 2017
Type: article
Study design: Observational Study
Abstract: The relationship between body-mass index (BMI) and Alzheimer´s disease (AD) has been extensively investigated. However, BMI alterations in preclinical individuals with autosomal dominant AD (ADAD) have not yet been investigated. We analyzed cross-sectional data from 230 asymptomatic members of families with ADAD participating in the Dominantly Inherited Alzheimer Network (DIAN) study including 120 preclinical mutation carriers (MCs) and 110 asymptomatic non-carriers (NCs). Differences in BMI and their relation with cerebral amyloid load and episodic memory as a function of estimated years to symptom onset (EYO) were analyzed. Preclinical MCs showed significantly lower BMIs compared to NCs, starting 11.2 years before expected symptom onset. However, the BMI curves begun to diverge already at 17.8 years before expected symptom onset. Lower BMI in preclinical MCs was significantly associated with less years before estimated symptom onset, higher global Aβ brain burden, and with lower delayed total recall scores in the logical memory test. The study provides cross-sectional evidence that weight loss starts one to two decades before expected symptom onset of ADAD. Our findings point toward a link between the pathophysiology of ADAD and disturbance of weight control mechanisms. Longitudinal follow-up studies are warranted to investigate BMI changes over time.
Source: Scientific Reports
Authors: Stephan Müller, Oliver Preische, Hamid R. Sohrabi, Susanne Gräber, Mathias Jucker, Janko Dietzsch, John M. Ringman, Ralph N. Martins, Eric McDade, Peter R. Schofield, Bernardino Ghetti, Martin Rossor, Neill R. Graff-Radford, Johannes Levin, Douglas Galasko, Kimberly A. Quaid, Stephen Salloway, Chengjie Xiong, Tammie Benzinger, Virginia Buckles, Colin L. Masters, Reisa Sperling, Randall J. Bateman, John C. Morris, Christoph Laske
Institutions: University of Tübingen, German Center for Neurodegenerative Diseases, Edith Cowan University, The University of Western Australia, Hertie Institute for Clinical Brain Research, University of Southern California, University of Pittsburgh, UNSW Sydney, Neuroscience Research Australia, Indiana University Indianapolis, UCL Queen Square Institute of Neurology, University College London, Mayo Clinic in Florida, Ludwig-Maximilians-Universität München, University of California San Diego, Brown University, Washington University in St. Louis, Mental Health Research Institute, The University of Melbourne, Brigham and Women's Hospital, Harvard University, Massachusetts General Hospital
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,673
OpenAlex ID: W2605938818