Work

Prostate organogenesis: tissue induction, hormonal regulation and cell type specification

Year: 2017

Type: review

Abstract: Prostate organogenesis is a complex process that is primarily mediated by the presence of androgens and subsequent mesenchyme-epithelial interactions. The investigation of prostate development is partly driven by its potential relevance to prostate cancer, in particular the apparent re-awakening of key developmental programs that occur during tumorigenesis. However, our current knowledge of the mechanisms that drive prostate organogenesis is far from complete. Here, we provide a comprehensive overview of prostate development, focusing on recent findings regarding sexual dimorphism, bud induction, branching morphogenesis and cellular differentiation.

Source: Development

DOI: 10.1242/dev.148270

Authors: Roxanne Toivanen, Michael M. Shen

Institutions: Herbert Irving Comprehensive Cancer Center, Columbia University

Language: English

Topic: Prostate Cancer Treatment and Research

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

Open Access status: bronze

Funders: National Institutes of Health, Medical Research Council, National Health and Medical Research Council, National Institute of Diabetes and Digestive and Kidney Diseases

Award: Progenitor cells of the mouse prostate epithelium