Surface EEG-Transcranial Direct Current Stimulation (tDCS) Closed-Loop System
Year: 2017
Type: article
Study design: Clinical Trial
Abstract: Conventional transcranial direct current stimulation (tDCS) protocols rely on applying electrical current at a fixed intensity and duration without using surrogate markers to direct the interventions. This has led to some mixed results; especially because tDCS induced effects may vary depending on the ongoing level of brain activity. Therefore, the objective of this preliminary study was to assess the feasibility of an EEG-triggered tDCS system based on EEG online analysis of its frequency bands. Six healthy volunteers were randomized to participate in a double-blind sham-controlled crossover design to receive a single session of 10[Formula: see text]min 2[Formula: see text]mA cathodal and sham tDCS. tDCS trigger controller was based upon an algorithm designed to detect an increase in the relative beta power of more than 200%, accompanied by a decrease of 50% or more in the relative alpha power, based on baseline EEG recordings. EEG-tDCS closed-loop-system was able to detect the predefined EEG magnitude deviation and successfully triggered the stimulation in all participants. This preliminary study represents a proof-of-concept for the development of an EEG-tDCS closed-loop system in humans. We discuss and review here different methods of closed loop system that can be considered and potential clinical applications of such system.
Language: English
Subfield: Neurology
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
Funders: Consortia for Improving Medicine with Innovation and Technology, European Commission, National Institutes of Health, Fundação para a Ciência e a Tecnologia, National Center for Complementary and Integrative Health, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Awards: G1297482482, G1516346500, G1763632427, EXECUTIVE DYSFUNCTIONING REHABILITATION IN PARKINSON DISEASE: AN INTENSIVE TDCS PARALLEL, DOUBLE BLIND, PLACEBO CONTROLLED RANDOMIZED INTERVENTION, G2673245850, G362919508, G3840324753, G3891694003, G4358898356, G4627546747, Aumentar a eficácia de estimulação eléctrica transcranial: Desenvolvimento de um sistema de loop fechado, G5224927334, GINSENG'S EFFECTS ON MRNA PROFILES IN A DIABETES-2 MODEL, G7713038420, G866422166, G8839327758, Pragmatic Trial of Remote tDCS and Somatosensory Training for Phantom Limb Pain with Machine Learning to Predict Treatment Response, Research Training in Complementary and Integrative Medicine
OpenAlex ID: W2606067425