Work

Composition and Function of Mammalian SWI/SNF Chromatin Remodeling Complexes in Human Disease

Year: 2016

Type: preprint

Abstract: Mammalian SWI/SNF (BAF) chromatin remodeling complexes play critical roles in maintaining chromatin architecture and gene expression. Genomic sequencing efforts over the past several years have unveiled a major role for these complexes in the development of human cancer as well as neurologic disease, prompting the need to interrogate underlying mechanisms and to develop new methods to comprehensively understand mSWI/SNF complex function. Here we discuss the emerging insights from genetic, biochemical, and functional genomic studies in the field and suggest approaches toward further basic investigations, as well as therapeutic targeting of chromatin remodeling machinery.

Source: Cold Spring Harbor Symposia on Quantitative Biology

DOI: 10.1101/sqb.2016.81.031021

Authors: John L. Pulice, Cigall Kadoch

Institutions: Broad Institute, Harvard University, Dana-Farber Cancer Institute

Language: English

Topic: Chromatin Remodeling and Cancer

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond