Early AMD-like defects in the RPE and retinal degeneration in aged mice with RPE-specific deletion of Atg5 or Atg7.
Year: 2017
Type: article
Abstract: PURPOSE: in mice as a function of age. METHODS: gene. Plastic and thin retinal sections were analyzed with light and electron microscopy for histological changes. Photoreceptor outer segment (POS) thickness in plastic sections was measured using the Adobe Photoshop CS4 extended ruler tool. Autophagic adaptor p62/SQSTM1 and markers for oxidatively damaged lipids, proteins, and DNA were examined with immunofluorescence staining of cryosections. Fluorescence signals were quantified using Image J software. RESULTS: mice with advanced age. CONCLUSIONS: predisposes but does not necessarily drive the development of AMD-like phenotypes or retinal degeneration.
Source: Europe PMC (PubMed Central)
Authors: Youwen Zhang, Samuel D Cross, James B Stanton, Alan D Marmorstein, Yun Zheng Le, Lihua Y Marmorstein
Language: English
Subfield: Ophthalmology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funder: National Eye Institute
OpenAlex ID: W2606524366