Work

Role and mechanism of action of leucine-rich repeat kinase 1 in bone

Year: 2017

Type: review

Abstract: Leucine-rich repeat kinase 1 (LRRK1) plays a critical role in regulating cytoskeletal organization, osteoclast activity, and bone resorption with little effect on bone formation parameters. Deficiency of Lrrk1 in mice causes a severe osteopetrosis in the metaphysis of the long bones and vertebrae bones, which makes LRRK1 an attractive alternative drug target for the treatment of osteoporosis and other high-turnover bone diseases. This review summarizes recent advances on the functions of the Lrrk1-related family members, Lrrk1 deficiency-induced skeletal phenotypes, LRRK1 structure–function, potential biological substrates and interacting proteins, and the mechanisms of LRRK1 action in osteoclasts.

Source: Bone Research

DOI: 10.1038/boneres.2017.3

Authors: Weirong R Xing, Helen Goodluck, Canjun Zeng, Subburaman Mohan

Institutions: Loma Linda University, Jerry L. Pettis Memorial VA Medical Center, Third Affiliated Hospital of Southern Medical University

Language: English

Topic: Bone Metabolism and Diseases

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,405