Tumor Microenvironment‐Triggered Supramolecular System as an In Situ Nanotheranostic Generator for Cancer Phototherapy
Year: 2017
Type: article
Abstract: The efficacy of photosensitizers in cancer phototherapy is often limited by photobleaching, low tumor selectivity, and tumor hypoxia. Assembling photosensitizers into nanostructures can improve photodynamic therapy efficacy and the safety profile of photosensitizers. Herein by employing supramolecular assembly, enhanced theranostic capability of Mn2+‐assisted assembly of a photosensitizer (sinoporphyrin sodium, DVDMS) is demonstrated. A tumor environment‐triggered coassembly strategy is further developed to form Mn/DVDMS nanotheranostics (nanoDVD) for cancer phototherapy. MnO2 nanosheets serve as a highly effective DVDMS carrier and in situ oxygen and nanoDVD generator. In MCF‐7 cells and xenograft tumors, MnO2/DVDMS is reduced by glutathione (GSH) and H2O2 and reassembled into nanoDVD, which can be monitored by activated magnetic resonance/fluorescence/photoacoustic signals. Intriguingly, the decrease of GSH, the production of O2, and the formation of nanoDVD are shown to be synergistic with phototherapy to improve antitumor efficacy in vitro and in vivo, offering a new avenue for cancer theranostics.
Source: Advanced Materials
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $6,070
Funders: National Natural Science Foundation of China, Natural Science Foundation of Fujian Province, Xiamen University, Major State Basic Research Development Program of China, National Institutes of Health, Program for New Century Excellent Talents in University, National Key Research and Development Program of China, Fundamental Research Funds for the Central Universities, National Institute of Biomedical Imaging and Bioengineering
Awards: G1122497904, G1183897342, Laboratory of Molecular Imaging and Nanomedicine, G2105430087, G2149659953, G2343109194, 程序化多功能结肠癌口服药物投递载体的构建及性能研究, G2763240224, G2780472844, G2895212994, G3188743252, G359850910, G4158466126, G5668987365, G5975053789, G6972888113, G7598691027, G7772809547, G7781557938, G877393814, G92131997
OpenAlex ID: W2606777299