Immunomodulation-accelerated neuronal regeneration following selective rod photoreceptor cell ablation in the zebrafish retina
Year: 2017
Type: article
Abstract: Significance Recent evidence suggests human retinal Müller glia retain a potential for neuronal regeneration. Defining the mechanisms governing retinal repair in robustly regenerative species may provide insights for harnessing this potential therapeutically. Here, we investigated roles of the innate immune system during rod photoreceptor regeneration in zebrafish. Our data establish a role for retinal microglia, the tissue-resident macrophage of the retina, in regulating retinal Müller glia responsiveness to cell death, and thereby controlling photoreceptor regeneration kinetics. Further, we show that immunosuppression can either inhibit or accelerate photoreceptor regeneration kinetics depending on the timing of treatment. We conclude that modulation of immune cell responses to retinal neuron cell death stands as a promising strategy for promoting repair of the human eye.
Authors: David T. White, Sumitra Sengupta, Meera T. Saxena, Qingguo Xu, Justin Hanes, Ding Ding, Hongkai Ji, Jeff S. Mumm
Institutions: Johns Hopkins University, Johns Hopkins Medicine
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: bronze
Awards: Targeted Cellular Ablation in Transgenic Zebrafish, G2856034156, Multiple Transgenic Models for Degenerative & Regenerative Research in Zebrafish, P30 Wilmer Core Grant for Vision Research, Genetic and Chemical Screens for Factors Regulating Retinal Regeneration, Robotic whole organism HTS platform for drug discovery and development, Visual Science Training Program
OpenAlex ID: W2606959512