Work

Neural mechanisms of oculomotor abnormalities in the infantile strabismus syndrome

Year: 2017

Type: review

Abstract: Infantile strabismus is characterized by numerous visual and oculomotor abnormalities. Recently nonhuman primate models of infantile strabismus have been established, with characteristics that closely match those observed in human patients. This has made it possible to study the neural basis for visual and oculomotor symptoms in infantile strabismus. In this review, we consider the available evidence for neural abnormalities in structures related to oculomotor pathways ranging from visual cortex to oculomotor nuclei. These studies provide compelling evidence that a disturbance of binocular vision during a sensitive period early in life, whatever the cause, results in a cascade of abnormalities through numerous brain areas involved in visual functions and eye movements.

Source: Journal of Neurophysiology

DOI: 10.1152/jn.00934.2016

Authors: Mark M. G. Walton, Adam Pallus, Jérome Fleuriet, Michael J. Mustari, Kristina Tarczy-Hornoch

Institutions: University of Washington, Seattle Children's Hospital

Language: English

Topic: Visual perception and processing mechanisms

Subfield: Cognitive Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Research to Prevent Blindness, National Institutes of Health, National Eye Institute, Office of Research Infrastructure Programs, National Institutes of Health