Genomic Characterization of Recrudescent Plasmodium malariae after Treatment with Artemether/Lumefantrine
Year: 2017
Type: article
Study design: Case Report
Abstract: Plasmodium malariae is the only human malaria parasite species with a 72-hour intraerythrocytic cycle and the ability to persist in the host for life. We present a case of a P. malariae infection with clinical recrudescence after directly observed administration of artemether/lumefantrine. By using whole-genome sequencing, we show that the initial infection was polyclonal and the recrudescent isolate was a single clone present at low density in the initial infection. Haplotypic analysis of the clones in the initial infection revealed that they were all closely related and were presumably recombinant progeny originating from the same infective mosquito bite. We review possible explanations for the P. malariae treatment failure and conclude that a 3-day artemether/lumefantrine regimen is suboptimal for this species because of its long asexual life cycle.
Source: Emerging infectious diseases
Language: English
Topic: Malaria Research and Control
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
Awards: Multi-gene families in malaria., G4839860845, Studentship DTG Competition 2011, Improving the treatment of Plasmodium vivax, G7597818247, Improving the treatment of Plasmodium vivax, Wellcome Trust Sanger Institute - generic account for deposition of all core- funded research papers, Pathophysiology and treatment of malaria and other tropical infectious diseases prevalent in our region
OpenAlex ID: W2607323535