Work

Diverse Modes of Reactivity of 6‐(Chloromethyl)‐6‐methylfulvene

Year: 2017

Type: article

Abstract: The title compound exhibits a number of reactivities toward nucleophiles/bases owing to the presence of several electrophilic and potentially nucleophilic sites in the molecule. We explored the reactions of 6-(chloromethyl)-6-methylfulvene with oxygen- and nitrogen nucleophiles and bases as well as a carbon-based nucleophile (an enamine) and realized all possible reactivity modes predicted on the basis of electrophilic and nucleophilic positions in this compound.

Source: European Journal of Organic Chemistry

DOI: 10.1002/ejoc.201700442

Authors: Ihsan Erden, Scott Gronert, Gabriel Cabrera, Necdet Coskun, Marco Tapken

Institutions: San Francisco State University, Virginia Commonwealth University, Bursa Uludağ Üni̇versi̇tesi̇

Language: English

Topic: Synthesis and Properties of Aromatic Compounds

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: National Science Foundation, National Institutes of Health, National Institute of General Medical Sciences

Awards: San Francisco State University MS/PhD Bridge to the Doctorate, MRI: Acquisition of a high resolution accurate mass spectrometer system, SFSU MBRS - RISE, The Fulvene Approach to the Syntheses of Antitumor Agents, Reactive Intermediates, Reaction Mechanisms, and Catalytic Cycles in the Gas Phase