Work

Extracellular Matrix Bioscaffolds as Immunomodulatory Biomaterials

Year: 2017

Type: review

Abstract: Suppression of the recipient immune response is a common component of tissue and organ transplantation strategies and has also been used as a method of mitigating the inflammatory and scar tissue response to many biomaterials. It is now recognized, however, that long-term functional tissue replacement not only benefits from an intact host immune response but also depends upon such a response. The present article reviews the limitations associated with the traditionally held view of avoiding the immune response, the ability of acellular biologic scaffold materials to modulate the host immune response and promote a functional tissue replacement outcome, and current strategies within the fields of tissue engineering and biomaterials to develop immune-responsive and immunoregulatory biomaterials.

Source: Tissue Engineering Part A

DOI: 10.1089/ten.tea.2016.0538

Authors: Jenna L. Dziki, Luai Huleihel, Michelle E. Scarritt, Stephen F. Badylak

Institutions: University of Pittsburgh, McGowan Institute for Regenerative Medicine

Language: English

Topic: Tissue Engineering and Regenerative Medicine

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute of Biomedical Imaging and Bioengineering