Work

Associations of α-thalassemia and BCL11A with stroke in Nigerian, United States, and United Kingdom sickle cell anemia cohorts

Year: 2017

Type: article

Study design: Observational Study

Abstract: =0.0002), but no association with frequent vaso-occlusive crises (≥3/year). A high-risk genetic profile is associated with increased hemolysis and stroke history in three independent cohorts. This profile may help identify patients to prioritize for hydroxyurea and for closer monitoring strategies for stroke.

Source: Blood Advances

DOI: 10.1182/bloodadvances.2017005231

Authors: Santosh L. Saraf, Titilola S. Akingbola, Binal N. Shah, Chinedu A. Ezekekwu, Omowunmi Sonubi, Xu Zhang, Lewis L. Hsu, Mark T. Gladwin, Roberto F. Machado, Richard S. Cooper, Victor R. Gordeuk, Bamidele O. Tayo

Institutions: University of Illinois Chicago, University College Hospital, Ibadan, University of Pittsburgh, Loyola University Chicago

Language: English

Topic: Hemoglobinopathies and Related Disorders

Subfield: Genetics

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,800

Funders: Doris Duke Charitable Foundation, National Heart, Lung, and Blood Institute, Fogarty International Center

Awards: G1163042056, G4497844540, G5818507648, Genetics and Genomics of Sickle Cell Nephropathy., G6620077792

OpenAlex ID: W2607789570

FWCI: 0.802

Cites: 34

Cited by: 15

Related to: 10