Work

Applications of Synthetic Organic Tetrasulfides as H2S Donors

Year: 2017

Type: article

Abstract: In an effort to expand the availability of simple polysulfides for H2S donation, we report here the synthesis and H2S release profiles of bis(aryl) and bis(alkyl) tetrasulfides. The tetrasulfide donors release H2S in a first-order dependence on reduced glutathione (GSH) and release more H2S than the commonly used trisulfide DATS.

Source: Organic Letters

DOI: 10.1021/acs.orglett.7b00858

Authors: Matthew M. Cerda, Matthew D. Hammers, Mary S. Earp, Lev N. Zakharov, Michael D. Pluth

Institution: University of Oregon

Language: English

Topic: Sulfur Compounds in Biology

Subfield: Biochemistry

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $4,500

Funders: Alfred P. Sloan Foundation, Camille and Henry Dreyfus Foundation, National Institute of General Medical Sciences