Work

Hypoxia inducible factor (HIF) as a model for studying inhibition of protein–protein interactions

Year: 2017

Type: article

Abstract: DM2 and Bcl-2 family of PPIs. However these important targets in oncology might be considered as "low-hanging-fruit". Hypoxia inducible factor (HIF) is an emerging, but not yet fully validated target for cancer chemotherapy. Its role is to regulate the hypoxic response and it does so through a plethora of protein-protein interactions of varying topology, topography and complexity: its modulation represents an attractive approach to prevent development of new vasculature by hypoxic tumours.

Source: Chemical Science

DOI: 10.1039/c7sc00388a

Authors: George M. Burslem, Hannah F. Kyle, Adam Nelson, Thomas A. Edwards, Andrew J. Wilson

Institution: University of Leeds

Language: English

Topic: Cancer, Hypoxia, and Metabolism

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond