Work

Density Guided MD-Rosetta Protocol for Protein Structure Refinement

Year: 2016

Type: other

Abstract: We have developed a combined Molecular dynamics (MD)-Rosetta protocol that incorporates cryo-electron microscopy data to improve protein structure refinement.This method uses two complementary approaches: Rosetta density guided model refinement via iterative local rebuilding of loops, and molecular dynamics flexible fitting methods.This combined MD-Rosetta protocol shows improvement over refinement with the individual methods.

Source: The Knowledge Bank (The Ohio State University)

Authors: Leelananda, Sumudu, Lindert, Steffen

Language: English

Topic: Protein Structure and Dynamics

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

OpenAlex ID: W2608193381

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