Work

Treat the Patient, Not Just the Cell!

Year: 2017

Type: editorial

Abstract: R ecently we have used reductionist and integrative approaches as pioneered by the seminal work of Sanguinetti and Keating to link human arrhythmias with gene mutations that alter the biophysical activity of channel proteins.But as we begin to seek new methodologies to treat heart disease, we are faced with a myriad of data that clearly simple cell-based assays or culture models cannot address on their own.Is it time to change course?Treat the Patient, Not Just the Cell!

Source: Circulation Research

DOI: 10.1161/circresaha.116.310427

Authors: Penelope A. Boyden, Peter J. Mohler

Institutions: The Ohio State University Wexner Medical Center, Columbia University

Language: English

Topic: Cardiac electrophysiology and arrhythmias

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: National Heart, Lung, and Blood Institute