Cobalt‐Catalyzed Alkylation of Secondary Alcohols with Primary Alcohols via Borrowing Hydrogen/Hydrogen Autotransfer
Year: 2017
Type: article
Abstract: Alcohols are promising sustainable starting materials because they can be obtained from abundant and indigestible biomass. The substitution of expensive noble metals in catalysis by earth abundant 3d metals, such as Mn, Fe, or Co, (nonprecious or base metals) is a related key concept with respect to sustainability. Here, we report on the first cobalt‐catalyzed alkylation of secondary alcohols with primary alcohols. Easy‐to‐synthesize and easy‐to‐activate PN 5 P‐pincer‐ligand‐stabilized Co complexes developed in our laboratory mediate the reaction most efficiently. The catalysis is applicable to a broad substrate scope and proceeds under relatively mild conditions. We have even demonstrated the coupling of a variety of purely aliphatic alcohols with a base or nonprecious metal catalyst. Mechanistic studies indicate that the reaction follows the borrowing hydrogen or hydrogen autotransfer concept.
Source: Chemistry - A European Journal
Authors: Frederik Freitag, Torsten Irrgang, Rhett Kempe
Institution: University of Bayreuth
Language: English
Subfield: Inorganic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: bronze
Funder: Deutsche Forschungsgemeinschaft
Award: G5692024569
OpenAlex ID: W2608560189