Year: 2017
Type: review
Abstract: Intracellular lipid droplets (LDs) are found in a wide variety of cell types and have been recognized as organelles with unique spherical structures. Although LDs are not stable lipid-depots, they are active sites of neutral lipid metabolism, and comprise neutral lipid or cholesterol cores surrounded by phospholipid monolayers containing specialized proteins. However, sizes and protein compositions vary between cell and tissue types. Proteins of the perilipin family have been associated with surfaces of LDs and all carry a conserved 11-mer repeat motif. Accumulating evidence indicates that all perilipins are involved in LD formation and that all play roles in LD function under differing conditions. In this brief review, we summarize current knowledge of the roles of perilipins and lipid metabolizing enzymes in a variety of mammalian cell types.
Source: Lipids in Health and Disease
Institutions: SHOWA Medical University, Kinjo Gakuin University
Language: English
Subfield: Biochemistry
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,990
Awards: Mechanisms of remodeling of white adipocytes to brown-like adipocytes (browning) in human mesenchymal stem cells., The role of lipid droplets in the steroid hormone synthesis in MLTC-1 mouse Leydig tumor cells., Biological and pharmaceutical study on intracellular lipid droplets which are the key organelle to understand life style diseases., G8398673346
OpenAlex ID: W2608630895