Comparison of general obesity and measures of body fat distribution in older adults in relation to cancer risk: meta-analysis of individual participant data of seven prospective cohorts in Europe
Year: 2017
Type: review
Abstract: We evaluated the associations of anthropometric indicators of general obesity (body mass index, BMI), an established risk factor of various cancer, and body fat distribution (waist circumference, WC; hip circumference, HC; and waist-to-hip ratio, WHR), which may better reflect metabolic complications of obesity, with total obesity-related and site-specific (colorectal and postmenopausal breast) cancer incidence. This is a meta-analysis of seven prospective cohort studies participating in the CHANCES consortium including 18 668 men and 24 751 women with a mean age of 62 and 63 years, respectively. Harmonised individual participant data from all seven cohorts were analysed separately and alternatively for each anthropometric indicator using multivariable Cox proportional hazards models. After a median follow-up period of 12 years, 1656 first-incident obesity-related cancers (defined as postmenopausal female breast, colorectum, lower oesophagus, cardia stomach, liver, gallbladder, pancreas, endometrium, ovary, and kidney) had occurred in men and women. In the meta-analysis of all studies, associations between indicators of adiposity, per s.d. increment, and risk for all obesity-related cancers combined yielded the following summary hazard ratios: 1.11 (95% CI 1.02–1.21) for BMI, 1.13 (95% CI 1.04–1.23) for WC, 1.09 (95% CI 0.98–1.21) for HC, and 1.15 (95% CI 1.00–1.32) for WHR. Increases in risk for colorectal cancer were 16%, 21%, 15%, and 20%, respectively per s.d. of BMI, WC, HC, and WHR. Effect modification by hormone therapy (HT) use was observed for postmenopausal breast cancer ( P interaction <0.001), where never HT users showed an ∼ 20% increased risk per s.d. of BMI, WC, and HC compared to ever users. BMI, WC, HC, and WHR show comparable positive associations with obesity-related cancers combined and with colorectal cancer in older adults. For postmenopausal breast cancer we report evidence for effect modification by HT use.
Source: British Journal of Cancer
DOI: 10.1038/bjc.2017.106
Authors: Heinz Freisling, Melina Arnold, Isabelle Soerjomataram, Mark George O'Doherty, José Manuel Ordóñez-Mena, Christina Bamia, Ellen Kampman, Michael Leitzmann, Isabelle Romieu, Frank Kee, Konstantinos Tsilidis, Anne Tjønneland, Antonia Trichopoulou, Paolo Boffetta, Vassiliki Benetou, H B(as) Bueno-de-Mesquita, José María Huerta, Hermann Brenner, Tom Wilsgaard, Mazda Jenab
Institutions: Centre international de recherche sur le cancer, Queen's University Belfast, German Cancer Research Center, Heidelberg University, University of Oxford, National and Kapodistrian University of Athens, Hellenic Health Foundation, Wageningen University & Research, University of Regensburg, University of Ioannina, Imperial College London, Danish Cancer Society, Icahn School of Medicine at Mount Sinai, University of Malaya, National Institute for Public Health and the Environment, Centro de Investigación Biomédica en Red, Instituto Murciano de Investigación Biosanitaria, Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, National Center for Tumor Diseases, Deutsches Konsortium für Translationale Krebsforschung, UiT The Arctic University of Norway
Language: English
Topic: Cancer Risks and Factors
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $5,190
Funders: World Health Organization, Universitetet i Tromsø, European Commission, Institut National de la Santé et de la Recherche Médicale, ZonMw, Bundesministerium für Bildung und Forschung, KWF Kankerbestrijding, Norges Forskningsråd, Hellenic Health Foundation, World Cancer Research Fund, Instituto de Salud Carlos III
OpenAlex ID: W2609284380