P18.01 The Neuro-Oncology Branch Patient Outcomes Program (POP)
Year: 2017
Type: conference-abstract
Abstract: The value of patient-centered outcomes research is increasingly being recognized as a means to assess the impact of the disease and therapy on the trajectory of an illness, in patients with solid tumor malignancies, including tumors of the central nervous system (CNS). Hypothesis-based research projects are integral to improving our knowledge of the impact of these tumors and their treatment on patients, mandating that survival measures be considered in the context of function and symptom burden. Comprehensive assessment requires integration of research that can accurately measure, predict risk, and explore the biologic basis of both symptoms and toxicity, with the goals of incorporating these parameters into treatment assessment and creating symptom treatment or prevention paradigms. Because of recognition of the importance of this aspect of clinical research, the Outcomes Section of the NOB has been developed with four areas of focus: (1) The development, establishing the utility and assessing the innovation of clinical outcomes assessments (COAs) for use in the primary brain tumor population; (2) Creating mechanisms and methodologies for incorporating clinical outcomes assessment (COAs) into brain tumor clinical trials; (3) Utilizing advanced data management, epidemiologic and informatics technologies, to identify clinical, genomic, and pathway-based predictors and mechanisms of toxicity; and (4) Optimizing patient outcomes by exploring new avenues of patient education and outreach to apply results from outcomes measures. Integrating research across disciplines and incorporation of bench-bedside-bench research is an essential component of the Outcomes Section, designed to provide a model of patient oriented clinical-translational research that may be useful in brain tumor as well as other areas of cancer research. An overview of the program including current projects and future directions will be provided.
Source: Neuro-Oncology
Authors: T. S. Armstrong, M. R. Gilbert
Institution: National Institutes of Health
Language: English
Topic: Cancer survivorship and care
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2609636751