Year: 2016
Type: article
Abstract: Aims: The present study is aimed at determining the antiviral activity of Eleusine indica whole plant methanol extract.Methodology and results: Whole dried plants were extracted with methanol and the solvent was evaporated using a rotary evaporator.The crude methanol extract was previously shown to have antiviral activity towards herpes simplex virus type 1 (HSV-1) with selective index (SI = CC50 / EC50) of 12.2.The extract was further studied for the possible mode of action including pretreatment, attachment, penetration or virucidal activity.The observations suggested that E. indica crude methanol extract protects cells from HSV-1 infection, inhibits virus from docking to the surface of the cells and penetrating into the cells, as well as modifying virus through the virucidal effect.Conclusion, significance and impact of study: Methanol extract of E. indica is safe with antiviral potential as a prophylactic agent, inhibits viral attachment, penetration and virucidal effect.
DOI: 10.21161/mjm.s01116
Authors: Iberahim, R., Ahamad Bahtiar, A., Ibrahim, N.
Institution: National University of Malaysia
Language: English
Topic: Medicinal Plant Research
Subfield: Plant Science
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $110
Award: G8419773104
OpenAlex ID: W2609649377